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Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy.
[cholangiocarcinoma]
In
this
study
,
the
effect
of
chlorin
e
6
-
based
photodynamic
therapy
(
Ce
6
-
PDT
)
was
investigated
in
human
intrahepatic
(
HuCC-
T
1
)
and
extrahepatic
(
SNU
1196
)
cholangiocarcinoma
(
CCA
)
cells
.
The
amount
of
intracellular
Ce
6
increased
with
increasing
Ce
6
concentration
administered
,
or
with
incubation
time
,
in
both
cell
lines
.
The
ability
to
take
up
Ce
6
and
generate
reactive
oxygen
species
after
irradiation
at
1
.
0
J
/
cm
(
2
)
did
not
significantly
differ
between
the
two
CCA
cell
types
.
However
,
after
irradiation
,
marked
differences
were
observed
for
photodamage
and
apoptotic
/
necrotic
signals
.
HuCC-
T
1
cells
are
more
sensitive
to
Ce
6
-
PDT
than
SNU
1196
cells
.
Total
glutathione
(
GSH
)
levels
,
glutathione
peroxidase
and
glutathione
reductase
activities
in
SNU
1196
cells
were
significantly
higher
than
in
HuCC-
T
1
cells
.
With
inhibition
of
enzyme
activity
or
addition
of
GSH
,
the
phototoxic
effect
could
be
controlled
in
CCA
cells
.
The
intracellular
level
of
GSH
is
the
most
important
determining
factor
in
the
curative
action
of
Ce
6
-
PDT
against
tumor
cells
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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