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Long-term outcome after surgical resection for cholangiocarcinoma and prognostic index value.
[cholangiocarcinoma]
To
investigate
the
prognostic
factors
of
patients
with
cholangiocarcinoma
and
establish
a
prognostic
model
to
evaluate
the
prognosis
.
169
cases
of
cholangiocarcinoma
were
analyzed
retrospectively
.
Clinicopathological
factors
were
evaluated
using
univariate
and
multivariate
analysis
.
Prognostic
index
(
PI
)
was
calculated
based
on
the
results
of
multivariate
analysis
.
Patients
with
different
PI
were
divided
into
3
groups
in
order
to
compare
the
survival
rate
of
each
group
and
draw
the
survival
curves
.
Individual
expected
survival
rate
was
calculated
based
on
the
prognostic
Cox
model
and
PI
.
The
PI
equation
was
built
that
included
all
significant
variables
and
coefficients
as
follow
formula
:
PI
=
(
β
1
×
lymph
node
metastasis
)
+
(
β
2
×
CEA
level
)
-
(
β
3
×
surgical
margin
)
.
Univariate
analysis
showed
that
CEA
,
lymph
node
metastasis
,
surgical
margin
,
AJCC
staging
,
tumor
differentiation
and
adjuvant
chemotherapy
were
prognostic
impacts
.
The
difference
was
statistically
significant
(
p
<
0
.
05
)
.
Cox
multivariate
analysis
showed
that
CEA
,
lymph
node
metastasis
and
surgical
margin
are
three
separate
prognostic
factors
.
According
to
different
PI
,
patients
were
divided
into
high
-risk
group
,
middle
-risk
group
and
low
-risk
group
and
three
groups
were
statistically
significant
difference
in
survival
rate
(
P
<
0
.
05
)
.
Racical
resection
is
the
key
to
improve
the
long
-term
survival
rate
of
cholangiocarcinoma
.
By
using
prognostic
Cox
model
and
the
PI
,
the
prognosis
of
patients
could
be
estimated
and
individualized
clinical
treatment
could
be
conducted
.
Diseases
Validation
Diseases presenting
"tumor differentiation"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
oral submucous fibrosis
werner syndrome
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