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A random Abstract
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Molecular diagnosis of intrahepatic cholangiocarcinoma.
[cholangiocarcinoma]
Intrahepatic
cholangiocarcinomas
(
iCCA
)
are
primary
intrahepatic
malignancies
originating
from
biliary
epithelia
.
While
both
hepatocellular
cancer
and
iCCA
can
present
as
mass
lesions
within
the
liver
,
these
cancers
are
distinct
in
their
morphology
,
etiology
,
pathology
,
natural
history
and
response
to
therapy
.
There
is
a
need
for
accurate
and
sensitive
molecular
markers
for
the
diagnosis
of
iCCA
.
Recent
advances
in
elucidating
molecular
and
genetic
characteristics
of
iCCA
offer
the
potential
of
molecular-based
diagnosis
of
iCCA
.
Specific
genetic
mutations
of
IDH
1
/
2
,
BAP
1
,
p
53
,
and
KRAS
,
FGFR
gene
fusions
and
alterations
in
microRNA
have
all
been
described
in
iCCA
.
Although
there
are
no
accurate
serum
or
biliary
biomarkers
currently
available
for
diagnosis
of
iCCA
,
several
potential
candidates
have
been
identified
.
Knowledge
of
specific
genetic
or
molecular
abnormalities
offers
potential
for
individualized
approaches
for
the
treatment
of
patients
with
iCCA
in
the
future
.
