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Alkali-treated titanium selectively regulating biological behaviors of bacteria, cancer cells and mesenchymal stem cells.
[cholangiocarcinoma]
Many
attentions
have
been
paid
to
the
beneficial
effect
of
alkali-treated
titanium
to
bioactivity
and
osteogenic
activity
,
but
few
to
the
other
biological
effect
.
In
this
work
,
hierarchical
micro
/
nanopore
films
were
prepared
on
titanium
surface
by
acid
etching
and
alkali
treatment
and
their
biological
effects
on
bacteria
,
cancer
cells
and
mesenchymal
stem
cells
were
investigated
.
Gram
-
positive
Staphylococcus
aureus
,
Gram
-negative
Escherichia
coli
,
and
human
cholangiocarcinoma
cell
line
RBE
were
used
to
investigate
whether
alkali-treated
titanium
can
influence
behaviors
of
bacteria
and
cancer
cells
.
Responses
of
bone
marrow
mesenchymal
stem
cells
(
BMMSCs
)
to
alkali-treated
titanium
were
also
subsequently
investigated
.
The
alkali-treated
titanium
can
potently
reduce
bacterial
adhesion
,
inhibit
RBE
and
BMMSCs
proliferation
,
while
can
better
promote
BMMSCs
osteogenesis
and
angiogenesis
than
acid-etched
titanium
.
The
bacteriostatic
ability
of
the
alkali-treated
titanium
is
proposed
to
result
from
the
joint
effect
of
micro
/
nanotopography
and
local
pH
increase
at
bacterium
/
material
interface
due
to
the
hydrolysis
of
alkali
(
earth
)
metal
titanate
salts
.
The
inhibitory
action
of
cell
proliferation
is
thought
to
be
the
effect
of
local
pH
increase
at
cell
/
material
interface
which
causes
the
alkalosis
of
cells
.
This
alkalosis
model
reported
in
this
work
will
help
to
understand
the
biologic
behaviors
of
various
cells
on
alkali-treated
titanium
surface
and
design
the
intended
biomedical
applications
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated