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EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3.
[cholangiocarcinoma]
To
investigate
the
impact
of
histone
methyltransferase
enhancer
of
zeste
homolog
2
(
EZH
2
)
on
the
proliferation
and
apoptosis
of
human
cholangiocarcinoma
cells
as
well
as
its
related
mechanisms
.
Immunohistochemistry
and
Western
blot
analyses
were
used
to
examine
the
expression
of
EZH
2
in
40
cases
of
human
cholangiocarcinoma
tissues
and
four
strains
of
human
cholangiocarcinoma
cells
.
The
influence
of
EZH
2
on
cell
growth
and
apoptosis
were
assessed
by
knockdown
experiments
,
and
a
xenograft
experiment
in
nude
mice
was
performed
to
evaluate
the
impact
of
siEZH
2
on
the
tumorigenicity
of
tumor
cells
.
The
correlation
of
EZH
2
,
clinic
pathological
features
and
overall
survival
rates
was
also
analyzed
.
EZH
2
was
highly
expressed
in
human
cholangiocarcinoma
tissues
and
cells
.
Silencing
of
EZH
2
could
significantly
reduce
the
methylation
level
of
RUNX
3
DNA
in
human
cholangiocarcinoma
cells
and
improve
its
protein
expression
as
well
as
inhibit
cell
proliferation
,
induce
apoptosis
and
slow
down
the
growth
of
tumor
in
nude
mice
.
In
addition
,
the
expression
of
EZH
2
was
associated
with
the
tumor
stage
,
lymph
node
positivity
and
poor
prognoses
.
Overexpression
of
EZH
2
can
promote
the
proliferation
of
cholangiocarcinoma
cells
and
inhibit
their
apoptosis
.
It
is
associated
with
poor
prognoses
in
patients
with
cholangiocarcinoma
.
Therefore
,
EZH
2
could
be
a
potential
clinical
therapeutic
target
for
the
treatment
of
cholangiocarcinoma
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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