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Outcomes of stereotactic body radiotherapy for unresectable primary or recurrent cholangiocarcinoma.
[cholangiocarcinoma]
To
report
the
results
of
stereotactic
body
radiotherapy
(
SBRT
)
for
unresectable
primary
or
recurrent
cholangiocarcinoma
.
From
January
2005
through
August
2013
,
58
patients
with
unresectable
primary
(
n
=
28
)
or
recurrent
(
n
=
30
)
cholangiocarcinoma
treated
by
SBRT
were
retrospectively
analyzed
.
The
median
prescribed
dose
was
45
Gy
in
3
fractions
(
range
,
15
to
60
Gy
in
1
-
5
fractions
)
.
Patients
were
treated
by
SBRT
only
(
n
=
53
)
or
EBRT
+
SBRT
boost
(
n
=
5
)
.
The
median
tumor
volume
was
40
mL
(
range
,
5
to
1
,
287
mL
)
.
The
median
follow-up
duration
was
10
months
(
range
,
1
to
97
months
)
.
The
1
-
year
,
2
-
year
overall
survival
rates
,
and
median
survival
were
45
%
,
20
%
,
and
10
months
,
respectively
.
The
median
survival
for
primary
group
and
recurrent
group
were
5
and
13
months
,
respectively
.
Local
control
rate
at
1
-
year
and
2
-
year
were
85
%
and
72
%
,
respectively
.
Disease
progression-free
survival
rates
at
1
-
year
and
2
-
year
were
26
%
and
23
%
,
respectively
.
In
univariate
analysis
,
ECOG
performance
score
(
0
-
1
vs
.
2
-
3
)
,
treatment
volume
(
<
50
vs
.
≥
50
mL
)
,
and
pre-
SBRT
CEA
level
(
<
5
vs
.
≥
5
ng
/
mL
)
were
significant
in
overall
survival
rate
.
In
multivariate
analysis
,
ECOG
score
(
p
=
0
.
037
)
and
tumor
volume
(
p
=
0
.
030
)
were
statistically
significant
.
In
the
recurrent
tumor
group
,
patients
with
>
12
months
interval
from
surgery
to
recurrence
showed
statistically
significant
higher
overall
survival
rate
than
those
with
≤
12
months
(
p
=
0
.
026
)
.
Six
patients
(
10
%
)
experienced
≥
grade
3
complications
.
SBRT
can
be
considered
as
an
effective
local
modality
for
unresectable
primary
or
recurrent
cholangiocarcinoma
.
Diseases
Validation
Diseases presenting
"experienced ≥grade 3 complications"
symptom
cholangiocarcinoma
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