Rare Diseases Symptoms Automatic Extraction
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How to access photodynamic therapy for bile duct carcinoma.
[cholangiocarcinoma]
Photodynamic
therapy
(
PDT
)
is
a
promising
treatment
option
for
local
control
of
remnant
cancer
after
surgical
resection
or
biliary
stenosis
by
the
unresectable
tumor
in
patients
with
bile
duct
carcinomas
(
BDC
)
.
To
achieve
effective
tumor
necrosis
,
an
appropriate
approach
to
laser
irradiation
is
necessary
.
The
efficacy
of
endoscopy-guided
PDT
using
porfimer
(
n
=
12
)
or
talaporfin
sodium
(
n
=
13
)
was
investigated
by
evaluating
the
transhepatic
biliary
routes
and
endoscopic
retrograde
biliary
(
ERB
)
routes
in
25
patients
with
BDC
.
Diseases
included
perihilar
intrahepatic
cholangiocarcinoma
(
ICC
)
in
four
patients
,
extrahepatic
BDCs
in
19
and
ampular
carcinoma
(
AC
)
in
two
patients
.
Adjuvant
PDT
after
surgical
resection
was
performed
in
18
patients
,
and
PDT
for
tumor
biliary
stenosis
was
performed
in
seven
.
In
patients
undergoing
surgical
resections
,
the
mean
period
between
the
operation
and
PDT
was
87
±
42
days
.
In
patients
who
underwent
prior
surgical
resections
,
the
transhepatic
route
was
used
in
five
(
28
%
)
,
the
jejunal
loop
was
used
in
11
(
61
%
)
,
the
T
-
tube
route
was
used
in
one
,
and
the
endoscopic
retrograde
cholangiography
(
ERC
)
route
via
papilla
Vater
was
used
in
one
.
In
unresectable
BDC
,
the
ERC
route
was
used
in
four
patients
(
57
%
)
,
and
the
transhepatic
biliary
route
was
used
in
three
(
43
%
)
.
Endoscopic-guided
PDT
could
not
be
performed
in
one
patient
because
of
a
technical
failure
.
Except
for
the
complication
of
photosensitivity
,
endoscopy-related
complications
were
not
observed
in
any
patients
.
Patients
undergoing
PDT
with
porfimer
sodium
had
a
significantly
longer
admission
period
compared
to
patients
undergoing
PDT
with
talaporfin
sodium
(
36
vs
.
5
days
,
respectively
)
(
P
<
0
.
01
)
.
PDT
was
safely
and
definitively
performed
using
the
endoscopy-guided
approach
via
the
transhepatic
or
ERC
route
.
By
considering
the
disadvantages
of
both
routes
,
PDT
must
be
adequately
achieved
for
local
control
of
BDC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated