Rare Diseases Symptoms Automatic Extraction

High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma.

[cholangiocarcinoma]

High expression of matrix metalloproteinase-9 (MMP-9) was found to be correlated with tumor progression and poor prognosis in a variety of carcinomas. However, few studies have investigated the role of MMP-9 in human hilar cholangiocarcinoma. In this study, a total of 58 patients with hilar cholangiocarcinoma who underwent curative resection were included in this study. The expression of MMP-9 was analyzed by immunohistochemistry using the streptavidin peroxidase complex method. The correlation of MMP-9 overexpression with clinicopathological features and survival time of patients was investigated. The results showed that MMP-9 overexpression was prominent in cancer cells and mainly localized in the cytoplasm. MMP-9 overexpression was observed in 46.5% tumors, which showed no correlation with clinicopathological parameters. Patients with high MMP-9 expression had a significantly poorer overall survival rate than those with negative or low MMP-9 expression (P = 0.038). Multivariate analysis confirmed that MMP-9 overexpression was an independent prognostic factor (P = 0.007). In conclusion, overexpression of MMP-9 is a valuable independent prognostic indicator in hilar cholangiocarcinoma.

Diseases presenting "high expression" symptom

  • carcinoma of the gallbladder
  • cholangiocarcinoma
  • esophageal adenocarcinoma
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • gm1 gangliosidosis
  • hodgkin lymphoma, classical
  • malignant atrophic papulosis
  • phenylketonuria
  • primary effusion lymphoma
  • severe combined immunodeficiency
  • waldenström macroglobulinemia
  • wiskott-aldrich syndrome

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