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High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma.
[cholangiocarcinoma]
High
expression
of
matrix
metalloproteinase-
9
(
MMP-
9
)
was
found
to
be
correlated
with
tumor
progression
and
poor
prognosis
in
a
variety
of
carcinomas
.
However
,
few
studies
have
investigated
the
role
of
MMP-
9
in
human
hilar
cholangiocarcinoma
.
In
this
study
,
a
total
of
58
patients
with
hilar
cholangiocarcinoma
who
underwent
curative
resection
were
included
in
this
study
.
The
expression
of
MMP-
9
was
analyzed
by
immunohistochemistry
using
the
streptavidin
peroxidase
complex
method
.
The
correlation
of
MMP-
9
overexpression
with
clinicopathological
features
and
survival
time
of
patients
was
investigated
.
The
results
showed
that
MMP-
9
overexpression
was
prominent
in
cancer
cells
and
mainly
localized
in
the
cytoplasm
.
MMP-
9
overexpression
was
observed
in
46
.
5
%
tumors
,
which
showed
no
correlation
with
clinicopathological
parameters
.
Patients
with
high
MMP-
9
expression
had
a
significantly
poorer
overall
survival
rate
than
those
with
negative
or
low
MMP-
9
expression
(
P
=
0
.
038
)
.
Multivariate
analysis
confirmed
that
MMP-
9
overexpression
was
an
independent
prognostic
factor
(
P
=
0
.
007
)
.
In
conclusion
,
overexpression
of
MMP-
9
is
a
valuable
independent
prognostic
indicator
in
hilar
cholangiocarcinoma
.
Diseases
Validation
Diseases presenting
"tumor progression"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
dedifferentiated liposarcoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
pleomorphic liposarcoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
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