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High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma.
[cholangiocarcinoma]
High
expression
of
matrix
metalloproteinase-
9
(
MMP-
9
)
was
found
to
be
correlated
with
tumor
progression
and
poor
prognosis
in
a
variety
of
carcinomas
.
However
,
few
studies
have
investigated
the
role
of
MMP-
9
in
human
hilar
cholangiocarcinoma
.
In
this
study
,
a
total
of
58
patients
with
hilar
cholangiocarcinoma
who
underwent
curative
resection
were
included
in
this
study
.
The
expression
of
MMP-
9
was
analyzed
by
immunohistochemistry
using
the
streptavidin
peroxidase
complex
method
.
The
correlation
of
MMP-
9
overexpression
with
clinicopathological
features
and
survival
time
of
patients
was
investigated
.
The
results
showed
that
MMP-
9
overexpression
was
prominent
in
cancer
cells
and
mainly
localized
in
the
cytoplasm
.
MMP-
9
overexpression
was
observed
in
46
.
5
%
tumors
,
which
showed
no
correlation
with
clinicopathological
parameters
.
Patients
with
high
MMP-
9
expression
had
a
significantly
poorer
overall
survival
rate
than
those
with
negative
or
low
MMP-
9
expression
(
P
=
0
.
038
)
.
Multivariate
analysis
confirmed
that
MMP-
9
overexpression
was
an
independent
prognostic
factor
(
P
=
0
.
007
)
.
In
conclusion
,
overexpression
of
MMP-
9
is
a
valuable
independent
prognostic
indicator
in
hilar
cholangiocarcinoma
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated