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High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma.
[cholangiocarcinoma]
High
expression
of
matrix
metalloproteinase-
9
(
MMP-
9
)
was
found
to
be
correlated
with
tumor
progression
and
poor
prognosis
in
a
variety
of
carcinomas
.
However
,
few
studies
have
investigated
the
role
of
MMP-
9
in
human
hilar
cholangiocarcinoma
.
In
this
study
,
a
total
of
58
patients
with
hilar
cholangiocarcinoma
who
underwent
curative
resection
were
included
in
this
study
.
The
expression
of
MMP-
9
was
analyzed
by
immunohistochemistry
using
the
streptavidin
peroxidase
complex
method
.
The
correlation
of
MMP-
9
overexpression
with
clinicopathological
features
and
survival
time
of
patients
was
investigated
.
The
results
showed
that
MMP-
9
overexpression
was
prominent
in
cancer
cells
and
mainly
localized
in
the
cytoplasm
.
MMP-
9
overexpression
was
observed
in
46
.
5
%
tumors
,
which
showed
no
correlation
with
clinicopathological
parameters
.
Patients
with
high
MMP-
9
expression
had
a
significantly
poorer
overall
survival
rate
than
those
with
negative
or
low
MMP-
9
expression
(
P
=
0
.
038
)
.
Multivariate
analysis
confirmed
that
MMP-
9
overexpression
was
an
independent
prognostic
factor
(
P
=
0
.
007
)
.
In
conclusion
,
overexpression
of
MMP-
9
is
a
valuable
independent
prognostic
indicator
in
hilar
cholangiocarcinoma
.
