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Terpenoids from the Root Bark of Pterolobium macropterum.
[cholangiocarcinoma]
Five
new
compounds
,
including
pteroloterins
A-C
(
1
,
3
,
and
4
)
,
1
β-acetoxytaepeenin
C
(
2
)
,
and
8
aα-hydroxycadinenal
(
5
)
,
and
11
known
compounds
were
isolated
from
the
root
bark
of
Pterolobium
macropterum
.
All
compounds
were
evaluated
for
cytotoxicity
against
the
cholangiocarcinoma
cell
lines
.
Compound
9
showed
weak
cytotoxicity
against
the
KKU-M
139
cell
line
with
an
IC
50
value
of
23
.
24
±
0
.
18
μM
and
showed
no
activity
against
normal
cells
.
Diseases
Validation
Diseases presenting
"weak cytotoxicity"
symptom
cholangiocarcinoma
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