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Osteopontin promoter polymorphisms at locus -443 are associated with metastasis and poor prognosis of human intrahepatic cholangiocarcinoma in Chinese population.
[cholangiocarcinoma]
Osteopontin
(
OPN
)
is
known
to
be
a
secreted
adhesive
glycoprotein
.
Role
of
OPN
in
human
intrahepatic
cholangiocarcinoma
(
ICC
)
has
not
been
well
understood
.
This
study
explored
whether
genetic
variations
in
the
osteopontin
gene
are
associated
with
ICC
risk
,
progression
and
metastasis
.
260
patients
with
stages
I
to
IV
between
2008
and
2013
were
recruited
in
this
study
and
same
number
healthy
persons
were
used
as
control
.
OPN-
66
T
/
G
,
-
156
G
/
GG
and
-
443
C
/
T
variants
were
genotyped
using
DNA
from
blood
lymphocytes
.
Chi
-square
test
and
a
Fisher
's
exact
test
were
used
to
analyze
the
genotype
distribution
between
healthy
subjects
and
patients
,
and
further
its
distribution
among
TNM
stages
and
incidence
metastasis
in
patients
.
For
the
variant
at
nt
-
443
(
CC
)
,
there
was
a
significant
difference
between
the
number
of
patients
with
stage
IV
and
those
with
all
other
stages
of
ICC
(
P
<
0
.
01
)
.
Patients
with
-
443
(
CC
)
variant
had
significant
higher
incidence
of
lymph
and
distant
metastasis
development
compared
to
other
genotypes
.
For
the
variant
at
nt
-
443
(
CT
)
,
there
was
a
significant
difference
between
the
number
of
ICC
patients
with
stage
III
+
IV
and
those
with
stage
I
+
II
(
P
<
0
.
01
)
.
The
survival
rates
for
ICC
patients
with
the
C
/
C
genotype
were
significantly
lower
than
for
patients
with
the
other
two
genotypes
(
C
/
T
,
T
/
T
)
.
OPN
-
443
C
/
T
polymorphism
is
a
potential
predictive
marker
of
metastasis
and
poor
prognosis
in
ICC
patients
.
Diseases
Validation
Diseases presenting
"blood lymphocytes"
symptom
cholangiocarcinoma
cowden syndrome
kallmann syndrome
monosomy 21
omenn syndrome
pyruvate dehydrogenase deficiency
scrub typhus
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