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Verruciform xanthoma: a special epidermal nevus.
[child syndrome]
Congenital
hemidysplasia
with
ichthyosiform
nevus
and
limb
defects
(
CHILD
)
syndrome
is
a
rare
X-
linked
hereditary
disorder
.
Presentation
varies
from
ichthyosiform
nevus
to
complete
limb
amelia
.
We
present
a
17
-
year
-old
adolescent
girl
who
presented
with
a
16
-
cm
exophytic
mass
of
the
right
foot
that
had
been
growing
for
7
years
as
well
as
knee
contracture
.
Deformed
nails
with
onychorrhexis
were
noted
bilaterally
.
History
of
multiple
nonlinear
erythematous
skin
lesions
covered
by
dry
waxy
scales
involving
multiple
body
folds
with
sharp
midline
demarcation
was
obtained
.
The
patient
's
family
history
was
negative
for
consanguinity
and
similar
conditions
.
Radiography
showed
right
leg
hypoplasia
and
osteopenia
.
These
findings
fulfill
the
diagnosis
of
CHILD
syndrome
.
Microscopically
,
psoriasiform
epidermal
hyperplasia
with
marked
orthohyper-keratosis
and
neutrophilic
exocytosis
were
noted
.
The
papillary
dermis
was
packed
with
foamy
macrophages
consistent
with
xanthomatous
changes
,
namely
verruciform
xanthoma
.
Verruciform
xanthoma
,
although
rarely
found
in
other
conditions
,
is
a
characteristic
finding
.
Diseases
Validation
Diseases presenting
"skin lesions"
symptom
child syndrome
cowden syndrome
cutaneous mastocytosis
cystinuria
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
familial mediterranean fever
focal myositis
gm1 gangliosidosis
heparin-induced thrombocytopenia
hirschsprung disease
junctional epidermolysis bullosa
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
oligodontia
omenn syndrome
papillon-lefèvre syndrome
primary effusion lymphoma
proteus syndrome
severe combined immunodeficiency
sneddon syndrome
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
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