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In vivo chemotherapeutic profile of human gallbladder small cell carcinoma.
[carcinoma of the gallbladder]
Small
cell
carcinoma
of
the
gallbladder
is
very
rare
,
but
shows
high
malignant
potential
with
frequent
metastasis
.
Chemotherapeutic
regimens
for
the
treatment
of
gallbladder
small
cell
carcinoma
have
not
yet
been
established
.
In
this
study
,
we
examined
in
vivo
chemosensitivity
tests
for
the
GB-
04
-
JCK
human
gallbladder
small
cell
carcinoma
,
which
were
previously
established
as
a
serial-transplantable
xenograft
in
nude
mice
.
We
used
four
anticancer
drugs
:
docetaxel
,
irinotecan
,
nedaplatine
and
gemcitabine
.
Docetaxel
maximally
suppressed
xenograft
tumor
growth
in
mice
(
P
<
0
.
01
)
,
and
showed
complete
tumor
regression
after
chemotherapy
day
35
.
Irinotecan
and
nedaplatine
suppressed
tumor
growth
without
complete
regression
(
P
<
0
.
01
)
.
Gemcitabine
did
not
affect
tumor
growth
significantly
.
This
in
vivo
experimental
study
proposed
chemotherapeutic
regimens
for
human
gallbladder
small
cell
carcinoma
.
Diseases
Validation
Diseases presenting
"complete tumor regression"
symptom
carcinoma of the gallbladder
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