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In vivo chemotherapeutic profile of human gallbladder small cell carcinoma.
[carcinoma of the gallbladder]
Small
cell
carcinoma
of
the
gallbladder
is
very
rare
,
but
shows
high
malignant
potential
with
frequent
metastasis
.
Chemotherapeutic
regimens
for
the
treatment
of
gallbladder
small
cell
carcinoma
have
not
yet
been
established
.
In
this
study
,
we
examined
in
vivo
chemosensitivity
tests
for
the
GB-
04
-
JCK
human
gallbladder
small
cell
carcinoma
,
which
were
previously
established
as
a
serial-transplantable
xenograft
in
nude
mice
.
We
used
four
anticancer
drugs
:
docetaxel
,
irinotecan
,
nedaplatine
and
gemcitabine
.
Docetaxel
maximally
suppressed
xenograft
tumor
growth
in
mice
(
P
<
0
.
01
)
,
and
showed
complete
tumor
regression
after
chemotherapy
day
35
.
Irinotecan
and
nedaplatine
suppressed
tumor
growth
without
complete
regression
(
P
<
0
.
01
)
.
Gemcitabine
did
not
affect
tumor
growth
significantly
.
This
in
vivo
experimental
study
proposed
chemotherapeutic
regimens
for
human
gallbladder
small
cell
carcinoma
.
Diseases
Validation
Diseases presenting
"tumor growth"
symptom
adrenal incidentaloma
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
primary effusion lymphoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
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