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Mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis and ulcerative colitis.
[carcinoma of the gallbladder]
Mucin-producing
carcinoma
of
the
gallbladder
is
very
rare
.
We
report
here
a
case
of
mucin-producing
carcinoma
of
the
gallbladder
associated
with
primary
sclerosing
cholangitis
(
PSC
)
and
ulcerative
colitis
(
UC
)
.
A
74
-
year
-old
female
had
been
treated
with
salazosulfapyridine
and
ursodesoxycholic
acid
becase
of
UC
and
PSC
.
After
7
years
of
treatment
,
laboratory
data
showed
that
the
liver
function
took
a
turn
for
the
worse
,
and
the
patient
was
admitted
to
our
hospital
for
further
examination
.
Enhanced
computed
tomography
and
ultrasonography
showed
an
enlarged
gallbladder
associated
with
wall
thickening
and
diffuse
papillary
protrusion
.
Endoscopic
retrograde
cholangiography
showed
stenosis
and
dilatation
of
the
bile
duct
,
which
were
compatible
with
PSC
.
Under
the
diagnosis
of
an
early
carcinoma
of
the
gallbladder
,
we
performed
simple
cholecystectomy
.
The
tumor
showed
a
papillary
growth
pattern
located
diffusely
in
the
gallbladder
with
a
massive
amount
of
mucin
filling
the
gallbladder
.
Histologically
,
it
was
diagnosed
as
a
papillary
adenocarcinoma
localized
in
the
mucosal
layer
.
To
the
best
of
our
knowledge
,
this
is
the
first
case
of
mucin-producing
carcinoma
of
the
gallbladder
associated
with
PSC
and
UC
.
PSC
and
UC
patients
should
be
regarded
as
a
high
-risk
group
not
only
for
cholangiocarcinoma
but
also
carcinoma
of
the
gallbladder
.
