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Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery.
[carcinoma of the gallbladder]
We
here
report
on
a
case
of
metachronous
multicentric
carcinomas
of
the
biliary
tract
treated
3
times
with
curative
surgery
over
23
years
.
A
28
-
year
-old
woman
underwent
cholecystectomy
because
of
papillary
carcinoma
of
the
gallbladder
.
After
17
years
,
3
carcinomas
developed
in
the
biliary
tract
:
intrahepatic
cholangiocarcinoma
of
the
left
liver
,
common
bile
duct
carcinoma
,
and
remnant
cystic
duct
carcinoma
.
They
were
successfully
removed
via
left
hepatectomy
combined
with
pylorus-preserving
pancreatoduodenectomy
.
Furthermore
,
another
intrahepatic
cholangiocarcinoma
developed
6
years
after
the
second
surgery
,
which
was
removed
again
via
partial
resection
of
the
posterior
segment
of
the
liver
.
Histological
findings
of
carcinomas
represented
various
grades
of
cell
differentiation
.
No
predisposition
toward
carcinogenesis
was
found
,
since
neither
pancreaticobiliary
maljunction
nor
primary
sclerosing
cholangitis
was
present
,
and
the
overexpression
of
cyclooxygenase-
2
was
negative
in
all
resected
specimens
.
Close
monitoring
for
recurrence
is
warranted
for
early
detection
of
metachronous
carcinoma
that
might
be
effectively
treated
with
repeated
resection
.
Diseases
Validation
Diseases presenting
"early detection"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
carcinoma of the gallbladder
child syndrome
cholangiocarcinoma
classical phenylketonuria
congenital diaphragmatic hernia
cowden syndrome
cystinuria
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal squamous cell carcinoma
fabry disease
homocystinuria without methylmalonic aciduria
inclusion body myositis
kallmann syndrome
krabbe disease
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pyomyositis
von hippel-lindau disease
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