Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study.

[carcinoma of the gallbladder]

We conducted this study to evaluate the optimal hepatic resection for pT 2 and pT 3 advanced carcinoma of the gallbladder without invasion of the hepatoduodenal ligament .We conducted a questionnaire survey regarding 4 ,243 cases of carcinoma of the gallbladder treated during the recent 10 -year period at 112 institutions belonging to the Japanese Society of Biliary Surgery . The questionnaires included questions on preoperative-diagnosis , complications , treatment , and surgical treatment , procedures of resection , surgical result , path histological findings , mode , and site of recurrence , additional post-operative treatment . They included 293 pT 2 and 192 pT 3 R 0 cases , which were negative for hepatoduodenal ligament invasion , and the cumulative survival rates and sites of postoperative recurrence in the form of liver metastasis , were retrospectively analyzed in these 485 cases .There were no significant differences in survival rate or recurrence rates in the form of liver metastasis between the groups that underwent resection of the gallbladder bed , the group that underwent segmentectomy 4 a +5 , and the group that underwent hepatectomy in patients with of both pT 2 or pT 3 gallbladder cancers . Our results also did not show that liver metastasis to segment 4 a 5 alone was particularly common .For gallbladder cancer , neither with hepatoduodenal ligament invasion nor hepatic invasion , resection of the gallbladder bed is more preferable for surgical hepatic procedure . For gallbladder cancer that invades any hepatic sites , a hepatic surgical procedure that could eliminate surgical margins would be desirable .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated