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Arginase activity in carcinoma of the gallbladder: a pilot study.
[carcinoma of the gallbladder]
Carcinoma
of
the
gallbladder
is
the
third
most
common
cancer
of
the
gastrointestinal
tract
.
Recent
studies
have
shown
increased
arginase
activity
in
various
malignancies
.
The
main
aim
of
this
study
was
to
evaluate
whether
arginase
activity
increases
in
carcinoma
of
the
gallbladder
.
The
arginase
activity
was
evaluated
in
serum
and
gallbladder
tissue
in
22
patients
with
histologically
proven
carcinoma
of
the
gallbladder
and
20
patients
with
cholecystitis
using
spectrophotometry
and
western
blot
assay
.
The
Student
's
t-test
,
analysis
of
variance
,
and
Student-
Newman-
Keuls
test
were
used
for
comparison
of
data
and
for
statistical
significance
.
The
mean
tissue
arginase
and
serum
arginase
activity
(
118
.
64
+
/
-
17
.
45
and
15
.
91
+
/
-
1
.
91
,
respectively
)
in
cases
of
carcinoma
of
the
gallbladder
were
significantly
higher
in
comparison
with
cholecystitis
(
86
.
37
+
/
-
4
.
45
and
12
.
73
+
/
-
0
.
72
,
respectively
)
.
Subgroup
analysis
showed
stage
III
gallbladder
carcinoma
had
the
maximum
tissue
arginase
activity
(
142
.
00
+
/
-
21
.
68
U
/
g
of
tissue
)
followed
by
stage
II
(
124
.
15
+
/
-
19
.
88
)
and
stage
I
(
108
.
46
+
/
-
6
.
73
)
.
This
significant
rise
in
mean
tissue
arginase
and
serum
arginase
activity
in
patients
with
gallbladder
cancer
probably
supports
an
association
between
arginase
activity
and
the
malignancy
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
