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Arginase activity in carcinoma of the gallbladder: a pilot study.
[carcinoma of the gallbladder]
Carcinoma
of
the
gallbladder
is
the
third
most
common
cancer
of
the
gastrointestinal
tract
.
Recent
studies
have
shown
increased
arginase
activity
in
various
malignancies
.
The
main
aim
of
this
study
was
to
evaluate
whether
arginase
activity
increases
in
carcinoma
of
the
gallbladder
.
The
arginase
activity
was
evaluated
in
serum
and
gallbladder
tissue
in
22
patients
with
histologically
proven
carcinoma
of
the
gallbladder
and
20
patients
with
cholecystitis
using
spectrophotometry
and
western
blot
assay
.
The
Student
's
t-test
,
analysis
of
variance
,
and
Student-
Newman-
Keuls
test
were
used
for
comparison
of
data
and
for
statistical
significance
.
The
mean
tissue
arginase
and
serum
arginase
activity
(
118
.
64
+
/
-
17
.
45
and
15
.
91
+
/
-
1
.
91
,
respectively
)
in
cases
of
carcinoma
of
the
gallbladder
were
significantly
higher
in
comparison
with
cholecystitis
(
86
.
37
+
/
-
4
.
45
and
12
.
73
+
/
-
0
.
72
,
respectively
)
.
Subgroup
analysis
showed
stage
III
gallbladder
carcinoma
had
the
maximum
tissue
arginase
activity
(
142
.
00
+
/
-
21
.
68
U
/
g
of
tissue
)
followed
by
stage
II
(
124
.
15
+
/
-
19
.
88
)
and
stage
I
(
108
.
46
+
/
-
6
.
73
)
.
This
significant
rise
in
mean
tissue
arginase
and
serum
arginase
activity
in
patients
with
gallbladder
cancer
probably
supports
an
association
between
arginase
activity
and
the
malignancy
.
