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Adenoendocrine cell carcinoma of the gallbladder clinically mimicking squamous cell carcinoma.
[carcinoma of the gallbladder]
We
present
the
case
of
a
62
-
year
-old
Japanese
man
whose
histological
diagnosis
was
adenoendocrine
cell
carcinoma
of
the
gallbladder
at
autopsy
,
but
whose
antemortem
diagnosis
was
squamous
cell
carcinoma
.
The
patient
was
admitted
to
hospital
with
complaints
of
occasional
vomiting
and
abdominal
pain
.
Abdominal
computed
tomography
revealed
a
large
tumor
on
the
gallbladder
involving
the
adjacent
liver
,
colon
,
and
duodenum
,
with
multiple
metastases
in
the
greater
omentum
and
paraportal
lymph
nodes
.
The
serum
level
of
squamous
cell
carcinoma
antigen
(
SCCA
)
was
high
,
whereas
that
of
carbohydrate
antigen
(
CA
)
19
-
9
,
as
well
as
that
of
carcinoembryonic
antigen
(
CEA
)
was
within
the
normal
range
.
Due
to
these
clinical
features
,
we
first
suspected
advanced
squamous
cell
carcinoma
of
the
gallbladder
.
After
two
cycles
of
gemcitabine
monotherapy
,
the
tumor
had
become
enlarged
and
the
regimen
was
changed
to
a
combination
of
docetaxel
and
cisplatin
.
Though
tumor
regression
was
achieved
and
his
serum
SCCA
level
normalized
after
3
months
,
the
patient
rejected
additional
chemotherapy
and
died
8
months
after
the
diagnosis
.
The
histopathological
findings
made
by
autopsy
demonstrated
the
tumor
to
be
an
adenoendocrine
cell
carcinoma
without
squamous
carcinoma
cells
.
The
case
is
interesting
in
that
the
clinical
features
were
similar
to
those
of
squamous
cell
carcinoma
of
the
gallbladder
.
