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Undifferentiated giant cell type carcinoma of the gallbladder with sarcomatoid dedifferentiation: a case report and review of the literature.
[carcinoma of the gallbladder]
Undifferentiated
gallbladder
carcinoma
is
a
rare
entity
.
Among
unusual
types
of
undifferentiated
gallbladder
carcinoma
,
giant
cell
type
carcinoma
is
infrequent
and
,
moreover
,
very
few
cases
of
such
neoplasms
with
osteoclast-like
giant
cells
have
been
documented
.
We
report
a
case
of
undifferentiated
gallbladder
carcinoma
presenting
an
unusual
immunophenotype
that
was
shown
to
be
of
giant
cell
type
with
sarcomatoid
dedifferentiation
infiltrated
by
osteoclast-like
multinucleated
cells
.
An
84
-
year
-old
Greek
man
presented
with
right
upper
quadrant
pain
,
high
fever
,
rigors
,
anorexia
and
weight
loss
during
the
past
month
.
Clinical
examination
revealed
tenderness
in
the
right
upper
abdominal
quadrant
and
a
palpable
gallbladder
.
Blood
tests
showed
elevated
white
blood
-cell
count
and
transaminases
.
Abdominal
ultrasound
and
computed
tomography
demonstrated
a
markedly
distended
gallbladder
,
measuring
16
cm
x
8
cm
,
with
oedema
and
pericholecystic
fluid
,
consistent
with
gallbladder
empyema
.
After
an
open
cholecystectomy
and
an
uneventful
recovery
,
the
patient
was
discharged
on
the
4
(
th
)
postoperative
day
.
On
cut
surface
,
a
2
cm
solid
mass
was
identified
,
obstructing
the
lumen
in
the
neck
of
the
gallbladder
.
Histopathology
and
immunohistochemistry
offered
the
diagnosis
of
an
undifferentiated
,
giant
cell
type
carcinoma
of
the
gallbladder
with
sarcomatoid
dedifferentiation
infiltrated
with
osteoclast-like
giant
cells
.
U
ndifferentiated
,
giant
cell
type
carcinoma
of
the
gallbladder
with
sarcomatoid
dedifferentiation
infiltrated
with
osteoclast-like
giant
cells
is
a
very
infrequent
neoplasm
.
Controversy
exists
over
its
nature
,
as
related
knowledge
remains
incomplete
.
Thorough
histopathological
and
immunohistochemical
evaluation
is
imperative
for
diagnosis
.
Due
to
their
rarity
,
the
biological
behaviour
and
prognosis
of
these
tumours
remain
unclear
.
Diseases
Validation
Diseases presenting
"computed tomography demonstrated a markedly distended gallbladder"
symptom
carcinoma of the gallbladder
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