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FU-MK-1 expression in human gallbladder carcinoma: an antigenic prediction marker for a better postsurgical prognosis.
[carcinoma of the gallbladder]
Gallbladder
carcinoma
is
an
aggressive
type
of
neoplasm
difficult
to
cure
by
conventional
procedures
.
Because
of
the
lack
of
reliable
markers
for
assessing
the
prognosis
,
this
retrospective
study
was
designed
to
investigate
the
prognostic
significance
of
MK
-
1
overexpression
in
human
carcinoma
of
the
gallbladder
.
Immunohistochemical
staining
using
monoclonal
antibody
FU-
MK
-
1
(
MK
-
1
antigen
)
was
performed
on
paraffin-embedded
tissues
from
63
patients
who
had
undergone
surgical
resection
for
gallbladder
carcinoma
.
Expression
of
MK
-
1
was
found
in
50
(
79
%
)
of
63
tumor
samples
.
All
21
papillary
and
12
of
13
well-differentiated
tubular
adenocarcinomas
but
only
1
of
8
poorly
differentiated
adenocarcinomas
were
positive
for
FU-
MK
-
1
.
Multivariate
analysis
showed
that
only
MK
-
1
expression
was
an
independent
prognostic
marker
(
P
=
.
0473
)
,
and
Kaplan-
Meier
curves
showed
that
MK
-
1
expression
was
significantly
related
to
increased
overall
survival
(
P
<
.
0001
)
.
These
results
suggest
that
MK
-
1
expression
is
a
prognostic
marker
in
gallbladder
carcinoma
.
Diseases
Validation
Diseases presenting
"type of neoplasm"
symptom
carcinoma of the gallbladder
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