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Simultaneous breast and ovarian metastasis from gallbladder carcinoma.
[carcinoma of the gallbladder]
Gallbladder
carcinoma
is
a
common
malignancy
in
the
Indian
subcontinent
.
It
commonly
metastasizes
through
lymphatics
,
direct
invasion
,
and
hematogenous
spread
.
A
common
extra
-
abdominal
site
of
metastasis
is
the
lungs
.
Simultaneous
metastasis
to
breast
and
ovary
is
extremely
rare
.
This
report
describes
an
unusual
case
of
carcinoma
gallbladder
metastasizing
to
the
breast
and
ovary
at
the
same
time
.
A
45
-
year
-old
woman
came
to
us
with
complaints
of
flatulent
dyspepsia
associated
with
weight
loss
and
anorexia
.
Ultrasound
of
the
abdomen
revealed
hepatomegaly
with
thick
-walled
gallbladder
with
multiple
stones
and
a
mass
at
the
fundus
,
but
normal
uterus
and
ovary
.
Contrast-enhanced
computer
tomography
of
the
abdomen
showed
a
gallbladder
mass
infiltrating
the
liver
parenchyma
.
The
patient
underwent
radical
cholecystectomy
.
Histopathological
examination
revealed
a
poorly
-differentiated
adenocarcinoma
with
mar-gins
free
from
tumor
infiltration
.
One
month
after
surgery
she
developed
a
breast
lump
.
Ultrasound
of
the
abdomen
for
metastatic
workup
revealed
an
ovary
mass
.
Simple
mastectomy
and
salphingo-opherectomy
were
performed
,
and
histopathological
examination
revealed
a
metastatic
adenocarcinoma
.
The
patient
is
now
on
chemotherapy
with
gemcitabin
.
This
is
an
unusual
case
of
carcinoma
of
the
gallbladder
with
metastasis
to
the
breast
and
ovary
,
which
has
not
been
documented
before
.
Diseases
Validation
Diseases presenting
"weight loss"
symptom
allergic bronchopulmonary aspergillosis
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
cholangiocarcinoma
cutaneous mastocytosis
dedifferentiated liposarcoma
dentinogenesis imperfecta
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
focal myositis
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
krabbe disease
oligodontia
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
von hippel-lindau disease
werner syndrome
This symptom has already been validated