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A case of signet-ring cell carcinoma of the gallbladder: immunohistochemistry and differential diagnosis.
[carcinoma of the gallbladder]
The
morphological
spectrum
of
gallbladder
carcinoma
is
broad
and
variable
.
Most
of
these
tumors
are
tubular
adenocarcinomas
.
There
are
some
tumors
with
unusual
morphology
that
may
be
difficult
to
classify
due
to
their
rarity
.
One
of
such
tumors
is
the
signet-ring
cell
carcinoma
,
which
is
a
highly
aggressive
,
mucin
producing
variant
of
gallbladder
adenocarcinoma
predominantly
or
exclusively
composed
of
signet-ring
cells
.
Histologically
,
these
tumors
are
similar
to
their
counterparts
in
other
organs
such
as
stomach
,
colon
and
breast
,
and
should
not
be
misinterpreted
as
metastatic
carcinoma
from
one
of
these
primary
sites
.
The
literature
about
this
variant
of
carcinoma
is
sparse
and
little
is
known
about
it
.
We
found
only
three
cases
of
signet-ring
cell
carcinoma
of
the
gallbladder
previously
reported
.
We
present
the
case
of
an
86
-
year
-old
woman
with
signet-ring
cell
carcinoma
of
the
gallbladder
and
discuss
the
potential
diagnostic
dilemmas
