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Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Adenosquamous
/
squamous
cell
carcinoma
(
AS
/
SCC
)
of
the
gallbladder
is
rarely
encountered
and
accounts
for
1
.
4
-
10
.
6
%
of
all
gallbladder
carcinomas
(
GBCs
)
.
This
study
was
conducted
to
investigate
the
clinicopathologic
features
of
AS
/
SCC
of
gallbladder
.
The
authors
retrospectively
reviewed
16
cases
of
pathologically
proven
AS
/
SCC
of
the
gallbladder
among
404
patients
who
underwent
surgery
for
GBC
from
October
1994
to
March
2009
.
Forty
-
eight
conventional
GBC
patients
were
selected
as
controls
after
matching
for
age
and
gender
.
Mean
patient
age
was
60
.
2
years
and
half
were
male
.
Tumor
stages
in
the
case
group
were
significantly
more
advanced
than
the
control
group
(
P
<
0
.
001
)
.
R
0
resection
rates
in
cases
and
controls
were
50
%
and
81
.
2
%
(
P
=
0
.
022
)
.
Overall
1
-
year
survival
in
the
case
group
was
significantly
poorer
than
in
the
control
group
(
18
.
8
%
vs
.
87
.
3
%
,
P
<
0
.
001
)
.
However
,
no
significant
difference
in
disease-free
survival
rates
was
found
between
cases
and
controls
after
R
0
resection
(
P
=
0
.
072
)
.
AS
/
SCC
of
the
gallbladder
is
often
diagnosed
at
an
advanced
stage
,
which
results
in
non-curative
surgical
resection
and
a
poorer
prognosis
than
conventional
GBC
.
However
,
curative
surgical
resection
of
AS
/
SCC
of
the
gallbladder
might
result
in
disease-free
survival
rates
that
are
comparable
with
those
of
conventional
GBC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated