Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case.
[carcinoma of the gallbladder]
Endoscopic
ultrasound-guided
fine-needle
aspiration
(
EUS-FNA
)
allows
a
reliable
and
accurate
diagnosis
of
neoplasms
of
the
gallbladder
and
bile
ducts
.
We
report
the
cytopathologic
findings
of
a
case
of
large
cell
neuroendocrine
carcinoma
(
LCNEC
)
of
the
gallbladder
and
extrahepatic
bile
ducts
in
a
67
-
year
-old
woman
who
presented
with
progressive
abdominal
pain
and
jaundice
.
EUS-FNA
of
the
mass
involving
the
common
bile
duct
and
of
a
porta
hepatis
lymph
node
showed
abundant
cellularity
with
tumor
cells
arranged
singly
and
occasionally
in
tight
and
loose
clusters
and
rosette-like
structures
in
a
background
showing
extensive
necrotic
debris
.
The
tumor
cells
were
predominantly
plasmacytoid
,
showed
a
moderate
amount
of
focally
vacuolated
cytoplasm
and
large
round
to
oval
hyperchromatic
nuclei
with
prominent
nucleoli
,
numerous
mitoses
,
and
apoptotic
bodies
.
The
differential
diagnosis
included
poorly
differentiated
adenocarcinoma
,
lymphoma
,
melanoma
,
and
poorly
differentiated
neuroendocrine
carcinoma
(
NEC
)
,
large
cell
type
.
The
tumor
cells
were
strongly
and
diffusely
positive
for
cytokeratin
AE
1
/
AE
3
,
CD
5
6
,
synaptophysin
,
and
chromogranin
and
showed
a
very
high
proliferative
fraction
on
Ki
67
staining
,
supporting
the
diagnosis
of
a
high
-grade
NEC
.
Due
to
the
large
size
of
the
neoplastic
cells
,
moderate
amounts
of
cytoplasm
and
prominent
nucleoli
,
a
diagnosis
of
LCNEC
was
made
on
the
EUS-FNA
sample
.
Despite
the
prompt
institution
of
chemotherapy
,
the
patient
died
shortly
thereafter
and
the
diagnosis
was
confirmed
at
autopsy
.
This
is
to
our
knowledge
the
first
case
of
LCNEC
of
the
gallbladder
and
bile
ducts
diagnosed
by
EUS-FNA
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom