Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case.
[carcinoma of the gallbladder]
Endoscopic
ultrasound-guided
fine-needle
aspiration
(
EUS-FNA
)
allows
a
reliable
and
accurate
diagnosis
of
neoplasms
of
the
gallbladder
and
bile
ducts
.
We
report
the
cytopathologic
findings
of
a
case
of
large
cell
neuroendocrine
carcinoma
(
LCNEC
)
of
the
gallbladder
and
extrahepatic
bile
ducts
in
a
67
-
year
-old
woman
who
presented
with
progressive
abdominal
pain
and
jaundice
.
EUS-FNA
of
the
mass
involving
the
common
bile
duct
and
of
a
porta
hepatis
lymph
node
showed
abundant
cellularity
with
tumor
cells
arranged
singly
and
occasionally
in
tight
and
loose
clusters
and
rosette-like
structures
in
a
background
showing
extensive
necrotic
debris
.
The
tumor
cells
were
predominantly
plasmacytoid
,
showed
a
moderate
amount
of
focally
vacuolated
cytoplasm
and
large
round
to
oval
hyperchromatic
nuclei
with
prominent
nucleoli
,
numerous
mitoses
,
and
apoptotic
bodies
.
The
differential
diagnosis
included
poorly
differentiated
adenocarcinoma
,
lymphoma
,
melanoma
,
and
poorly
differentiated
neuroendocrine
carcinoma
(
NEC
)
,
large
cell
type
.
The
tumor
cells
were
strongly
and
diffusely
positive
for
cytokeratin
AE
1
/
AE
3
,
CD
5
6
,
synaptophysin
,
and
chromogranin
and
showed
a
very
high
proliferative
fraction
on
Ki
67
staining
,
supporting
the
diagnosis
of
a
high
-grade
NEC
.
Due
to
the
large
size
of
the
neoplastic
cells
,
moderate
amounts
of
cytoplasm
and
prominent
nucleoli
,
a
diagnosis
of
LCNEC
was
made
on
the
EUS-FNA
sample
.
Despite
the
prompt
institution
of
chemotherapy
,
the
patient
died
shortly
thereafter
and
the
diagnosis
was
confirmed
at
autopsy
.
This
is
to
our
knowledge
the
first
case
of
LCNEC
of
the
gallbladder
and
bile
ducts
diagnosed
by
EUS-FNA
.
Diseases
Validation
Diseases presenting
"lymphoma"
symptom
adrenal incidentaloma
alpha-thalassemia
carcinoma of the gallbladder
cushing syndrome
dedifferentiated liposarcoma
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
liposarcoma
locked-in syndrome
monosomy 21
oculocutaneous albinism
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
This symptom has already been validated