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Potential biomarkers in gallbladder cancer: present status and future directions.
[carcinoma of the gallbladder]
Carcinoma
of
the
gallbladder
(
GBC
)
is
the
most
common
biliary
tree
cancer
in
the
world
.
Beside
gallstones
,
no
specific
risk
factors
for
GBC
are
currently
established
.
Several
published
studies
have
identified
various
prognostic
gene
expression
markers
in
GBC
.
T
he
present
article
reviewed
published
studies
on
gene
expression
biomarkers
and
gallbladder
cancer
susceptibility
.
We
searched
the
PubMed
,
Medline
,
and
Embase
databases
using
the
search
terms
"
Gallbladder
"
,
"
cancer
/
carcinoma
"
,
"
expression
"
,
"
genes
"
,
"
proteins
"
,
and
"
biomarker
"
updated
until
June
2012
and
limited
to
English
language
papers
.
The
online
searching
was
accompanied
by
checking
reference
lists
from
the
identified
articles
for
potentially
eligible
original
reports
.
Potential
GBC
biomarkers
identified
by
different
studies
were
summarized
.
To
infer
,
the
present
article
highlights
a
few
potential
biomarkers
in
GBC
.
However
,
none
of
the
markers
identified
so
far
are
effective
as
a
routine
screening
test
in
GBC
.
Diseases
Validation
Diseases presenting
"identified articles for potentially eligible original reports"
symptom
carcinoma of the gallbladder
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