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Undifferentiated spindle-cell carcinoma of the gallbladder: a report of a case, an immunohistochemistry profile, and a review of the literature.
[carcinoma of the gallbladder]
Undifferentiated
spindle-cell
carcinoma
is
a
rare
gallbladder
cancer
with
a
worse
or
similar
prognosis
to
the
generally
dismal
outcome
seen
in
most
gallbladder
cancer
patients
.
We
reported
a
case
of
SpCC
,
stage
IV
disease
that
was
initially
diagnosed
as
undifferentiated
pleomorphic
sarcoma
,
but
deeper
sections
revealed
few
clusters
of
epithelioid
clear
cells
.
Although
the
tumour
showed
biphasic
appearances
on
haematoxylin
and
eosin
,
it
exhibited
poor
protein
expression
with
most
sarcoma
markers
being
negative
except
for
focal
vimentin
positivity
.
The
CEA
and
CK
7
were
positive
only
in
the
epithelioid
clear
cell
clusters
while
CD
68
positive
was
also
focally
positive
in
the
spindle-cell
component
.
The
poor
tumour
differentiation
coupled
with
advanced
stage
at
presentation
was
partly
responsible
for
the
disease
progression
and
patients
'
death
one
year
after
surgery
.
Early
diagnosis
and
surgical
intervention
with
better
understanding
of
this
tumour
biology
may
offer
improved
prognosis
and
survival
in
this
rare
cancer
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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