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Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience.
[carcinoma of the gallbladder]
This
report
examines
the
patterns
of
presentation
,
prognostic
factors
and
survival
rate
of
all
patients
with
gallbladder
cancer
(
GBC
)
evaluated
at
our
tertiary
academic
hospital
over
an
11
-
year
period
.
A
retrospective
review
of
a
prospectively
collected
database
of
all
patients
with
GBC
presenting
between
January
1998
and
December
2008
was
performed
.
102
GBC
-patients
were
included
:
69
women
and
33
men
(
median
age
:
65
,
5
years
)
.
Forty
-
five
patients
presented
with
incidental
gallbladder
cancer
(
IGC
)
and
57
with
nonincidental
cancer
(
NIGC
)
.
Curative
surgery
rate
was
84
.
4
%
for
IGC
and
29
.
8
%
for
NIGC
(
p
<
0
.
001
)
.
Five
-
year
actuarial
survival
rate
was
63
.
2
%
for
patients
with
curative
intent
surgery
and
0
%
for
patients
with
palliative
approach
.
Patients
with
IGC
had
a
longer
survival
rate
compared
to
patients
with
NIGC
(
median
:
25
.
8
vs
.
4
.
4
months
,
p
<
0
.
0001
)
.
For
patients
with
radical
resection
(
42
patients
)
,
there
was
no
difference
between
IGC
and
NIGC
.
The
incidence
of
liver
involvement
was
respectively
0
%
,
20
.
8
%
,
58
.
3
%
,
100
%
for
pT
1
,
pT
2
,
pT
3
and
pT
4
tumors
.
Univariate
analysis
showed
that
survival
rate
was
significantly
affected
by
perineural
invasion
,
T
,
N
and
M-
stage
,
R
0
resection
,
liver
involvement
,
CA
-
19
.
9
.
In
multivariate
analysis
,
liver
involvement
was
the
only
independent
factor
.
Majority
of
patients
with
a
potentially
curable
disease
had
IGC
.
Almost
80
%
of
patients
with
NIGC
presented
with
unresectable
disease
.
For
patients
who
underwent
resection
with
curative
intent
,
actuarial
5
-
year
survival
was
63
.
2
%
.
Liver
involvement
was
the
only
independent
prognostic
factor
.
All
patients
with
IGC
and
a
pT
2
or
more
advanced
T
stage
should
undergo
a
second
radical
resection
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated