[Prevalence and sequence of metaplasia-dysplasia-carcinoma of the gallbladder. A single centre retrospective study].

[carcinoma of the gallbladder]

We report the frequency and age of metaplasia , dysplasia and carcinoma of the gallbladder , and seek to establish a sequence of progression of these , since several studies suggest that this is the carcinogenesis pathway .Descriptive retrospective cross-sectional study over a period of 4 years , with an analytical component of 1 ,514 patients with cholelithiasis , in whom cholecystectomy were performed .The mean age of the sample was 46 years and 72 % of patients were female . The prevalence (and mean age ) of pyloric metaplasia , intestinal metaplasia , dysplasia and carcinoma was 22 .6 (47 ), 2 .1 (46 ), 0 .2 (54 ) and 0 .6 % (63 years ), respectively . There was a significant association between intestinal and pyloric metaplasia (P <.001 , chi (2 )) and between dysplasia and carcinoma (P <.005 , Yates ), but not between metaplasia and dysplasia .Improved studies should be conducted for the correct interpretation of the pathogenesis of gallbladder cancer .