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Clinicopathologic analysis of undifferentiated carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Undifferentiated
carcinoma
(
UC
)
of
the
gallbladder
(
GB
)
is
a
rare
malignant
neoplasm
and
there
have
only
been
sparse
case
reports
without
precise
description
.
We
analyzed
eight
cases
of
UC
of
GB
and
compared
with
gallbladder
carcinoma
(
GBC
)
in
the
aspects
of
clinicopathologic
characteristics
and
prognosis
.
We
found
eight
UC
cases
out
of
238
surgically
resected
GBCs
.
Patients
with
stage
-matched
GBC
were
selected
(
1
:
4
)
for
comparative
analysis
of
the
clinicopathologic
features
and
survival
of
UC
.
H
istologically
,
UC
cases
were
composed
of
four
sarcomatoid
,
two
pleomorphic
,
one
small
cell
,
and
one
osteoclast-like
giant
cell
types
.
There
was
no
difference
between
UC
and
ordinary
GBC
in
clinicopathologic
parameters
,
except
for
tumor
size
.
It
was
significantly
larger
in
UC
(
median
;
5
.
0
cm
,
ranging
1
.
3
-
10
.
0
cm
)
compared
to
GBC
(
median
;
3
.
0
cm
,
ranging
1
.
5
-
9
.
0
cm
,
P
=
0
.
01
)
.
UC
presented
frequent
intraluminal
polypoid
mass
(
87
.
5
%
:
7
/
8
)
.
UC
showed
significantly
poor
overall
survival
rate
(
37
.
5
%
,
37
.
5
%
and
18
.
8
%
at
1
,
3
,
and
5
years
)
,
than
GBC
(
84
.
4
%
,
65
.
6
%
and
52
.
1
%
,
respectively
)
(
P
=
0
.
005
)
.
Pathologic
findings
of
UC
were
an
independent
prognostic
factor
for
poor
survival
in
GBC
(
HR
7
.
242
,
95
%
confidence
interval
:
1
.
799
-
29
.
147
)
.
Undifferentiated
carcinoma
of
the
gallbladder
was
a
rare
highly
malignant
neoplasm
and
frequently
presented
a
large
intraluminal
polypoid
tumor
.
It
showed
a
significantly
larger
tumor
size
and
poorer
survival
than
GBC
.
Diseases
Validation
Diseases presenting
"poorer survival than gbc"
symptom
carcinoma of the gallbladder
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