Rare Diseases Symptoms Automatic Extraction
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Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy.
[carcinoma of the gallbladder]
Biliary
drainage
was
performed
in
a
71
-
year
-old
man
with
obstructive
jaundice
of
unknown
origin
;
however
,
he
died
due
to
acute
pulmonary
failure
.
At
autopsy
,
proliferation
of
adenocarcinoma
cells
was
observed
in
the
gallbladder
mucosa
transitioning
from
isolated
signet-ring
cell
carcinoma
(
SRCC
)
to
the
subserosa
and
bile
ducts
without
growth
toward
the
gallbladder
lumen
.
Furthermore
,
fibrocellular
intimal
proliferation
,
tumor
emboli
and
organized
thrombi
were
observed
in
the
small
pulmonary
arteries
.
The
final
diagnosis
was
gallbladder
carcinoma
complicated
by
SRCC
associated
pulmonary
tumor
thrombotic
microangiopathy
(
PTTM
)
.
PTTM
may
present
as
rapidly
progressive
dyspnea
,
and
a
high
level
of
clinical
suspicion
is
required
to
make
the
differential
diagnosis
.