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Our Project
Our Team
[Pathological analysis of heroin spongiform leukoencephalopathy].
[canavan disease]
To
investigate
the
pathological
characteristics
of
heroin
spongiform
leukoencephalopathy
(
HSLE
)
.
Cerebral
tissue
specimens
were
obtained
from
15
patients
with
HSLE
and
the
histological
observations
under
optical
and
electron
microscopes
were
carried
out
by
HE
,
Bielschowsky
's
,
and
chromotrope
2
R-
brilliant
green
staining
.
HSLE
was
characterized
primarily
by
spongiform
vacuolar
degeneration
of
the
cerebral
white
matter
.
Neurons
in
the
gray
matter
,
Purkinje
and
granular
cells
in
the
cerebella
remain
intact
in
all
the
cases
.
Numerous
vacuoles
,
which
merged
to
form
larger
cavities
,
appeared
in
the
damaged
white
matter
,
and
the
axons
survived
in
the
deep
white
matter
.
The
myelin
sheath
in
the
cerebellar
white
matter
sustained
more
severe
damages
than
those
in
the
cerebral
white
matter
.
No
vacuoles
or
lymphocyte
infiltration
occurred
in
the
small
peripheral
vessels
.
HSLE
is
pathologically
characterized
by
vacuolar
degeneration
due
to
primary
damage
of
the
myelin
,
and
the
spongiform
vacuolar
degeneration
is
closely
associated
with
the
severity
of
demyelination
in
the
white
matter
.
Diseases
Validation
Diseases presenting
"cerebral tissue specimens"
symptom
canavan disease
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