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[Roles of bcl-2/bax expression and oligodendrocyte apoptosis in the pathogenesis of heroin-induced spongiform leucoencephalopathy].
[canavan disease]
To
investigate
the
role
of
oligodendrocyte
apoptosis
under
the
regulation
of
the
bcl-
2
/
bax
protein
expression
in
brain
white
matter
in
the
pathogenesis
of
heroin-induced
spongiform
leucoencephalopathy
(
HSLE
)
.
Samples
of
frontal
lobe
,
cerebellum
,
and
corpus
callosum
were
obtained
from
the
brains
during
autopsy
of
4
HSLE
cases
and
5
normal
controls
and
underwent
light
microscopy
and
electron
microscopy
.
Immunocytochemistry
was
used
to
detect
the
expression
of
myelin
basic
protein
(
MBP
)
,
caspase-
3
,
bcl-
2
protein
,
and
bax
protein
.
Widespread
demyelination
was
seen
in
the
white
matter
of
the
frontal
lobe
,
cerebellum
and
corpus
callosum
of
the
HSLE
cases
,
most
severely
in
the
cerebellum
.
The
levels
of
caspase-
3
and
bax
expression
of
the
HSLE
group
were
significantly
higher
than
those
of
the
control
group
(
both
P
<
0
.
05
)
,
however
,
the
bcl-
2
level
of
the
HSLE
group
was
no
significantly
different
from
that
of
the
control
group
(
P
>
0
.
05
)
.
Widespread
demyelination
in
the
white
matter
is
a
prevailed
pathological
change
of
HSLE
.
Oligodendrocyte
apoptosis
under
induced
by
the
decrease
of
bcl-
2
/
bax
ratio
may
contribute
to
the
pathogenesis
.
Diseases
Validation
Diseases presenting
"corpus callosum"
symptom
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
classical phenylketonuria
cohen syndrome
gm1 gangliosidosis
hirschsprung disease
hydrocephalus with stenosis of the aqueduct of sylvius
kabuki syndrome
kallmann syndrome
krabbe disease
monosomy 21
neonatal adrenoleukodystrophy
oligodontia
proteus syndrome
pyruvate dehydrogenase deficiency
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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