Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Roles of bcl-2/bax expression and oligodendrocyte apoptosis in the pathogenesis of heroin-induced spongiform leucoencephalopathy].
[canavan disease]
To
investigate
the
role
of
oligodendrocyte
apoptosis
under
the
regulation
of
the
bcl-
2
/
bax
protein
expression
in
brain
white
matter
in
the
pathogenesis
of
heroin-induced
spongiform
leucoencephalopathy
(
HSLE
)
.
Samples
of
frontal
lobe
,
cerebellum
,
and
corpus
callosum
were
obtained
from
the
brains
during
autopsy
of
4
HSLE
cases
and
5
normal
controls
and
underwent
light
microscopy
and
electron
microscopy
.
Immunocytochemistry
was
used
to
detect
the
expression
of
myelin
basic
protein
(
MBP
)
,
caspase-
3
,
bcl-
2
protein
,
and
bax
protein
.
Widespread
demyelination
was
seen
in
the
white
matter
of
the
frontal
lobe
,
cerebellum
and
corpus
callosum
of
the
HSLE
cases
,
most
severely
in
the
cerebellum
.
The
levels
of
caspase-
3
and
bax
expression
of
the
HSLE
group
were
significantly
higher
than
those
of
the
control
group
(
both
P
<
0
.
05
)
,
however
,
the
bcl-
2
level
of
the
HSLE
group
was
no
significantly
different
from
that
of
the
control
group
(
P
>
0
.
05
)
.
Widespread
demyelination
in
the
white
matter
is
a
prevailed
pathological
change
of
HSLE
.
Oligodendrocyte
apoptosis
under
induced
by
the
decrease
of
bcl-
2
/
bax
ratio
may
contribute
to
the
pathogenesis
.
