Rare Diseases Symptoms Automatic Extraction
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Upregulation of N-acetylaspartic acid induces oxidative stress to contribute in disease pathophysiology.
[canavan disease]
N-
acetylaspartic
acid
(
NAA
)
is
predominantly
present
in
brain
and
also
present
in
lower
amount
in
peripheral
organs
.
The
role
of
NAA
in
pathophysiology
is
poorly
understood
.
Therefore
the
review
was
aimed
to
understand
contribution
of
NAA
in
disease
process
.
Amniotic
fluid
of
mothers
with
Canavan
disease
(
CD
)
fetus
and
patients
with
the
disease
show
increased
levels
of
NAA
.
Increase
of
this
pathway
is
also
reported
in
Parkinson
's
disease
and
type
2
diabetes
.
In
HIV-related
dementia
,
NAA
is
affected
.
Recent
studies
suggest
that
upregulation
of
NAA
leads
to
oxidative
stress
including
upregulation
of
nitric
oxide
and
reducing
potential
antioxidants
.
NAA
also
leads
to
physiological
abnormalities
including
walking
disorder
.
These
changes
suggest
that
NAA
contributes
in
disease
pathophysiology
.
