Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Relationship between heroin spongiform leucoencephalopathy and respiratory chain complex I deficiency].
[canavan disease]
To
investigate
the
relationship
between
heroin
spongiform
leucoencephalopathy
and
respiratory
chain
complex
I
deficiency
.
T
he
activity
of
respiratory
chain
complex
I
in
peripheral
white
blood
cell
mitochondria
was
compared
between
36
cases
of
heroin
spongiform
leucoencephalopathy
and
36
healthy
subjects
using
enzyme-linked
immunosorbent
assay
(
ELISA
)
.
The
activity
of
respiratory
chain
complex
I
was
5
.
6
∓
2
.
4
U
/
ml
in
patients
with
heroin
spongiform
leucoencephalopathy
,
significantly
higher
than
that
in
the
normal
subjects
(
4
.
2
∓
2
.
1
U
/
ml
,
t
=
2
.
634
,
P
<
0
.
05
)
.
In
patients
with
heroin
spongiform
leucoencephalopathy
,
mitochondrial
dysfunction
results
in
energy
metabolism
disorder
to
cause
extensive
demyelination
of
the
cerebral
white
matter
.
Respiratory
chain
complex
I
deficiency
of
the
mitochondria
plays
a
significant
role
in
the
pathogenesis
of
heroin
spongiform
leucoencephalopathy
.
Diseases
Validation
Diseases presenting
"mitochondrial dysfunction"
symptom
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
inclusion body myositis
neonatal adrenoleukodystrophy
oral submucous fibrosis
pyruvate dehydrogenase deficiency
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated