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Headache among CADASIL patients with R544C mutation: prevalence, characteristics, and associations.
[cadasil]
There
are
variations
of
migraine
prevalence
in
cerebral
autosomal
dominant
arteriopathy
with
subcortical
infarcts
and
leukoencephalopathy
(
CADASIL
)
among
different
regions
of
the
world
.
Previous
studies
on
Asian
CADASIL
patients
have
not
provided
detailed
descriptions
of
the
characteristics
of
their
headaches
.
The
aims
of
this
study
were
to
determine
prevalence
and
characteristics
of
headaches
and
to
investigate
associations
between
headache
and
other
clinical
symptoms
or
brain
magnetic
resonance
imaging
(
MRI
)
findings
among
homogenous
group
of
patients
having
the
same
R
544
C
mutation
.
In
this
cross-sectional
study
,
we
enrolled
53
CADASIL
patients
with
the
R
544
C
mutation
between
May
2010
and
April
2011
.
We
obtained
the
history
of
headache
using
a
structured
questionnaire
and
detailed
interview
.
Other
clinical
features
and
brain
MRI
findings
were
also
assessed
for
potential
associations
.
Overall
headache
prevalence
was
45
.
3
%
(
24
patients
)
.
Among
them
,
21
patients
(
87
.
5
%
)
were
classified
as
having
tension-
type
headache
,
followed
by
migraine
(
two
patients
)
and
unclassifiable
headaches
(
one
patient
)
.
Except
for
alcohol
consumption
,
no
significant
associations
were
observed
between
the
headaches
and
other
clinical
features
or
brain
MRI
findings
.
Migraine
was
found
in
only
3
.
8
%
of
CADASIL
patients
with
the
R
544
C
mutation
.
Such
a
low
prevalence
of
migraine
may
hinder
clinical
detection
of
CADASIL
among
ethnically
Asian
patients
.
Diseases
Validation
Diseases presenting
"headaches"
symptom
alexander disease
cadasil
cutaneous mastocytosis
familial hypocalciuric hypercalcemia
hydrocephalus with stenosis of the aqueduct of sylvius
sneddon syndrome
thoracic outlet syndrome
This symptom has already been validated