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Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL.
[cadasil]
CADASIL
is
the
most
frequent
hereditary
small
-vessel
disease
of
the
brain
.
The
clinical
impact
of
various
MR
imaging
markers
has
been
repeatedly
studied
in
this
disorder
,
but
alterations
of
contrast
between
gray
matter
and
normal-appearing
white
matter
remain
unknown
.
The
aim
of
this
study
was
to
evaluate
the
contrast
alterations
between
gray
matter
and
normal-appearing
white
matter
on
T
1
-
weighted
images
in
patients
with
CADASIL
compared
with
healthy
subjects
.
Contrast
between
gray
matter
and
normal-appearing
white
matter
was
assessed
by
using
histogram
analyses
of
3
D
T
1
high
-resolution
MR
imaging
in
23
patients
with
CADASIL
at
the
initial
stage
of
the
disease
(
Mini-
Mental
State
Examination
score
>
24
and
modified
Rankin
scale
score
≤
1
;
mean
age
,
53
.
5
±
11
.
1
years
)
and
30
age-
and
sex-matched
controls
.
T
1
contrast
between
gray
matter
and
normal-appearing
white
matter
was
significantly
reduced
in
patients
compared
with
age-
and
sex-matched
controls
(
patients
:
1
.
35
±
0
.
08
versus
controls
:
1
.
43
±
0
.
04
,
P
<
10
(
-
5
)
)
.
This
reduction
was
mainly
driven
by
a
signal
decrease
in
normal-appearing
white
matter
.
Contrast
loss
was
strongly
related
to
the
volume
of
white
matter
hyperintensities
.
Conventional
3
D
T
1
imaging
shows
significant
loss
of
contrast
between
gray
matter
and
normal-appearing
white
matter
in
CADASIL
.
This
probably
reflects
tissue
changes
in
normal-appearing
white
matter
outside
signal
abnormalities
on
T
2
or
FLAIR
sequences
.
These
contrast
alterations
should
be
taken
into
account
for
image
interpretation
and
postprocessing
.
Diseases
Validation
Diseases presenting
"white matter hyperintensities"
symptom
22q11.2 deletion syndrome
cadasil
hereditary cerebral hemorrhage with amyloidosis
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