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Molecular basis of young ischemic stroke.
[cadasil]
Epidemiological
and
family
studies
have
provided
evidence
on
the
role
of
genetic
factors
in
stroke
,
particularly
in
stroke
occurring
at
young
age
.
However
,
despite
its
impact
,
young
stroke
continues
to
be
understudied
.
This
article
reviews
the
existing
literature
on
the
most
investigated
monogenic
disorders
(
CADASIL
,
Fabry
disease
,
MELAS
,
RVCL
,
COL
4
A
1
,
Marfan
and
Ehlers-
Danlos
syndromes
)
causing
stroke
in
young
and
a
number
of
candidate
genes
associated
with
stroke
occurring
in
patients
younger
than
50
years
.
Although
our
study
failed
in
identifying
strong
and
reliable
associations
between
specific
genes
and
young
stroke
,
our
detailed
literature
revision
on
the
field
allowed
us
to
compile
a
panel
of
genes
possibly
generating
a
susceptibility
to
stroke
,
which
could
be
a
starting
point
for
future
research
.
Since
stroke
is
a
potentially
preventable
disease
,
the
identification
of
genes
associated
with
young
stroke
may
promote
novel
prevention
strategies
and
allow
the
identification
of
therapeutic
disease
targets
.
Diseases
Validation
Diseases presenting
"provided evidence on the role of genetic factors in stroke"
symptom
cadasil
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