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Dementia in middle-aged patients with schizophrenia.
[cadasil]
Although
numerous
studies
have
assessed
cognitive
dysfunction
in
patients
with
schizophrenia
,
very
few
have
focused
on
the
diagnosis
of
dementia
.
Our
objectives
were
to
accurately
diagnose
dementia
in
a
cohort
of
middle
-aged
patients
with
schizophrenia
and
to
assess
the
type
of
dementia
.
96
patients
with
schizophrenia
(
46
inpatients
and
50
outpatients
)
,
aged
50
to
70
years
,
underwent
a
psychiatric
,
neurological
,
and
neuropsychological
evaluation
at
baseline
and
after
a
20
-
month
follow-up
.
We
established
a
3
-
step
procedure
:
1
)
diagnose
dementia
according
to
the
DSM
-IV
criteria
,
using
the
Mattis
Dementia
Rating
and
Activities
of
Daily
Living
scales
;
2
)
characterize
dementia
using
brain
imaging
,
perfusion
by
99
mTc-
ECD
-SPECT
and
laboratory
tests
including
Alzheimer
's
disease
cerebrospinal
fluid
biomarkers
;
and
3
)
search
for
genetic
determinants
.
Fourteen
patients
fulfilled
the
diagnostic
criteria
of
dementia
.
Four
were
diagnosed
with
possible
or
probable
behavioral
-variant
frontotemporal
dementia
(
bvFTD
)
,
two
with
probable
Alzheimer
's
disease
,
two
with
probable
vascular
dementia
(
including
one
due
to
CADASIL
)
,
one
with
CNS
inflammatory
disease
,
and
six
could
not
be
fully
characterized
.
The
diagnosis
of
dementia
in
middle
-aged
patients
with
schizophrenia
is
challenging
but
possible
,
using
a
multistep
procedure
.
The
most
frequent
condition
,
bvFTD
,
could
reflect
the
presence
of
an
evolutive
neurodegenerative
process
in
some
patients
.
Diseases
Validation
Diseases presenting
"assessed cognitive dysfunction in patients with schizophrenia"
symptom
cadasil
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