Rare Diseases Symptoms Automatic Extraction
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ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
[cadasil]
Diffusion
tensor
imaging
(
DTI
)
histogram
metrics
are
correlated
with
clinical
parameters
in
cerebral
small
vessel
diseases
(
cSVD
)
.
Whether
ADC
histogram
parameters
derived
from
simple
diffusion
weighted
imaging
(
DWI
)
can
provide
relevant
markers
for
long
term
studies
of
cSVD
remains
unknown
.
CADASIL
patients
were
evaluated
by
DWI
and
DTI
in
a
large
cohort
study
over
a
6
-
year
period
.
ADC
histogram
parameters
were
compared
to
those
derived
from
mean
diffusivity
(
MD
)
histograms
in
280
patients
using
intra-class
correlation
and
Bland-
Altman
plots
.
Impact
of
image
corrections
applied
to
ADC
maps
was
assessed
and
a
mixed
effect
model
was
used
for
analyzing
the
effects
of
scanner
upgrades
.
The
results
showed
that
ADC
histogram
parameters
are
strongly
correlated
to
MD
histogram
parameters
and
that
image
corrections
have
only
limited
influence
on
these
results
.
Unexpectedly
,
scanner
upgrades
were
found
to
have
major
effects
on
diffusion
measures
with
DWI
or
DTI
that
can
be
even
larger
than
those
related
to
patients
'
characteristics
.
These
data
support
that
ADC
histograms
from
daily
used
DWI
can
provide
relevant
parameters
for
assessing
cSVD
,
but
the
variability
related
to
scanner
upgrades
as
regularly
performed
in
clinical
centers
should
be
determined
precisely
for
longitudinal
and
multicentric
studies
using
diffusion
MRI
in
cSVD
.