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In vivo high-resolution 7 Tesla MRI shows early and diffuse cortical alterations in CADASIL.
[cadasil]
Recent
data
suggest
that
early
symptoms
may
be
related
to
cortex
alterations
in
CADASIL
(
Cerebral
Autosomal-
Dominant
Arteriopathy
with
Subcortical
Infarcts
and
Leukoencephalopathy
)
,
a
monogenic
model
of
cerebral
small
vessel
disease
(
SVD
)
.
The
aim
of
this
study
was
to
investigate
cortical
alterations
using
both
high
-resolution
T
2
*
acquisitions
obtained
with
7
Tesla
MRI
and
structural
T
1
images
with
3
Tesla
MRI
in
CADASIL
patients
with
no
or
only
mild
symptomatology
(
modified
Rankin
's
scale
≤
1
and
Mini
Mental
State
Examination
(
MMSE
)
≥
24
)
.
Complete
reconstructions
of
the
cortex
using
7
Tesla
T
2
*
acquisitions
with
0
.
7
mm
isotropic
resolution
were
obtained
in
11
patients
(
52
.
1
±
13
.
2
years
,
36
%
male
)
and
24
controls
(
54
.
8
±
11
.
0
years
,
42
%
male
)
.
Seven
Tesla
T
2
*
within
the
cortex
and
cortical
thickness
and
morphology
obtained
from
3
Tesla
images
were
compared
between
CADASIL
and
control
subjects
using
general
linear
models
.
MMSE
,
brain
volume
,
cortical
thickness
and
global
sulcal
morphology
did
not
differ
between
groups
.
By
contrast
,
T
2
*
measured
by
7
Tesla
MRI
was
significantly
increased
in
frontal
,
parietal
,
occipital
and
cingulate
cortices
in
patients
after
correction
for
multiple
testing
.
These
changes
were
not
related
to
white
matter
lesions
,
lacunes
or
microhemorrhages
in
patients
having
no
brain
atrophy
compared
to
controls
.
Seven
Tesla
MRI
,
by
contrast
to
state
of
the
art
post-processing
of
3
Tesla
acquisitions
,
shows
diffuse
T
2
*
alterations
within
the
cortical
mantle
in
CADASIL
whose
origin
remains
to
be
determined
.
Diseases
Validation
Diseases presenting
"cortical alterations"
symptom
cadasil
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