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Multimodal Retinal Vessel Analysis in CADASIL Patients.
[cadasil]
To
further
elucidate
retinal
findings
and
retinal
vessel
changes
in
Cerebral
autosomal
dominant
arteriopathy
with
subcortical
infarcts
and
leukoencephalopathy
(
CADASIL
)
patients
by
means
of
high
resolution
retinal
imaging
.
28
eyes
of
fourteen
CADASIL
patients
and
an
equal
number
of
control
subjects
underwent
confocal
scanning
laser
ophthalmoscopy
(
cSLO
)
,
spectral-domain
optical
coherence
tomography
(
SD
-
OCT
)
,
retinal
nerve
fibre
layer
(
RNFL
)
measurements
,
fluorescein
and
indocyanine
angiography
.
Three
vessel
measurement
techniques
were
applied
:
RNFL
thickness
,
a
semiautomatic
software
tool
based
on
cSLO
images
and
manual
vessel
outlining
based
on
SD
-
OCT
.
Mean
age
of
patients
was
56
.
2
±
11
.
6
years
.
Arteriovenous
nicking
was
present
in
22
(
78
.
6
%
)
eyes
and
venous
dilation
in
24
(
85
.
7
%
)
eyes
.
Retinal
volume
and
choroidal
volume
were
8
.
77
±
0
.
46
mm
3
and
8
.
83
±
2
.
24
mm
3
.
RNFL
measurements
showed
a
global
increase
of
105
.
2
µm
(
98
.
4
µm
;
p
=
0
.
015
)
.
Based
on
semi-automatic
cSLO
measurements
,
maximum
diameters
of
arteries
and
veins
were
102
.
5
µm
(
106
.
0
µm
;
p
=
0
.
21
)
and
128
.
6
µm
(
124
.
4
µm
;
p
=
0
.
27
)
respectively
.
Manual
SD
-
OCT
measurements
revealed
significantly
increased
mean
arterial
138
.
7
µm
(
125
.
4
µm
;
p
<
0
.
001
)
and
venous
160
.
0
µm
(
146
.
9
;
p
=
0
.
003
)
outer
diameters
as
well
as
mean
arterial
27
.
4
µm
(
19
.
2
µm
;
p
<
0
.
001
)
and
venous
18
.
3
µm
(
15
.
7
µm
;
p
<
0
.
001
)
wall
thicknesses
in
CADASIL
patients
.
The
findings
reflect
current
knowledge
on
pathophysiologic
changes
in
vessel
morphology
in
CADASIL
patients
.
SD
-
OCT
may
serve
as
a
complementary
tool
to
diagnose
and
follow-up
patients
suffering
from
cerebral
small
-vessel
diseases
.
Diseases
Validation
Diseases presenting
"retinal vessel changes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy"
symptom
cadasil
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