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Congenital estrogen deficiency: in search of the estrogen role in human male reproduction.
[aromatase deficiency]
Recently
,
a
remarkable
progress
has
been
made
in
our
understanding
about
the
role
of
sex
steroids
in
male
physiology
.
In
this
paper
,
we
consider
the
clinical
aspects
of
congenital
estrogen
deficiency
-
notably
,
estrogen
resistance
and
aromatase
deficiency
-
in
men
and
we
discuss
both
well-established
and
supposed
estrogen
roles
in
the
human
male
reproductive
function
.
These
topics
include
the
role
of
estrogens
in
the
control
of
gonadotropin
secretion
,
in
male
fertility
determination
and
psychosexual
behavior
.
Briefly
,
estrogens
play
a
pivotal
role
in
the
control
of
serum
gonadotropin
concentrations
in
the
human
male
.
Furthermore
,
a
possible
role
of
estrogens
on
both
human
male
fertility
and
sexuality
has
also
been
suggested
by
recent
studies
,
even
though
the
available
data
are
far
from
being
conclusive
.
Conversely
,
for
what
concern
fertility
and
sexual
behavior
,
a
well-established
effect
of
estrogens
has
been
provided
by
recent
studies
on
male
rodents
,
which
show
impaired
sexual
behavior
and
fertility
as
a
consequence
of
estrogen
defect
.
Diseases
Validation
Diseases presenting
"human male fertility"
symptom
aromatase deficiency
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