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Role of estrogen on bone in the human male: insights from the natural models of congenital estrogen deficiency.
[aromatase deficiency]
The
reports
of
congenital
estrogen
deficiency
-
notably
,
estrogen
resistance
and
aromatase
deficiency
-
have
completely
changed
our
knowledge
on
the
role
of
estrogen
on
bone
in
males
.
Particularly
,
the
bone
changes
at
puberty
,
which
were
classically
considered
androgen-dependent
,
are
now
considered
to
be
induced
at
least
in
part
by
estrogen
action
.
Clinical
cases
of
congenital
estrogen
deficiency
have
clearly
demonstrated
that
the
role
of
estrogens
in
epiphyseal
closure
,
skeletal
proportions
and
bone
mineralization
is
crucial
not
only
in
women
but
also
in
men
.
In
addition
progress
have
been
made
in
the
treatment
of
such
a
rare
disease
even
though
further
studies
are
needed
to
a
definitive
understanding
of
this
issue
.
Diseases
Validation
Diseases presenting
"skeletal proportions and bone mineralization is crucial not only in women but also in men"
symptom
aromatase deficiency
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