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Corneal ulceration due to vitamin A deficiency in Zellweger syndrome.
[zellweger syndrome]
We
report
a
case
of
vitamin
A
deficiency
and
secondary
corneal
ulcer
in
an
infant
with
Zellweger
syndrome
.
A
7
-
month
-old
infant
with
failure
to
thrive
and
malnutrition
developed
a
corneal
ulcer
.
Fortified
antibiotic
eye
drops
were
administered
without
improvement
.
Vitamin
A
deficiency
was
suspected
and
confirmed
.
Supplementation
with
oral
vitamin
A
decreased
corneal
opacification
.
Zellweger
syndrome
was
later
diagnosed
.
Vitamin
A
deficiency
should
be
considered
in
the
differential
diagnosis
of
nonhealing
corneal
ulcers
in
children
,
especially
those
with
systemic
syndromes
and
failure
to
thrive
.